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Protein Folding Dynamics

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Prem P. Chapagain, PhD

Associate Professor
Department of Physics
Florida International University
11200 SW 8th St
CP 204
Miami, FL 33199
Ph: 305-348-6266
Fax: 305-348-6700
Email: prem.chapagain@fiu.edu


Research Highlights:

The Theoretical Biophysics Group at FIU is involved in several research projects in the area of biological physics. The major projects include theoretical and computational investigations of protein folding dynamics, protein aggregation, and protein engineering. The group is equipped with several workstations and two Linux clusters.

 In addition to the thermodynamics and statistical mechanics of protein folding and aggregation of model peptide systems, I am interested in investigating the dynamics and photophysical properties of fluorescent proteins using detailed all-atom molecular dynamics simulations. My research interests also include  broadly related fields of biological physics such as mathematical modeling of the dynamics of infectious diseases, self-organization and complexity.

Recent Publications:

Geraldine Fulcrand, Samantha Dages, Xiaoduo Zhi, Prem Chapagain, Bernard Gerstman, David Dunlap, and Fenfei Leng  “DNA supercoiling, a critical signal regulating the basal expression of the lac operon in Escherichia coli” Scientific Reports 6, 19243 (2016).
Rahul Mittal,  Brandon Chan, M'hamed Grati, Jeenu Mittal, Kunal Patel, Luca H. Debs, Amit P. Patel, Denise Yan, Prem Chapagain, and Xue Zhong Liu “Molecular Structure and Regulation of P2X Receptors With a Special Emphasis on the Role of P2X2 in the Auditory System” J. Cell. Physiol. 9999, 1–15 (2015).
Jeevan B. GC, Bernard S. Gerstman, and Prem P. Chapagain, “The Role of the Interdomain Interactions on RfaH Dynamics and Conformational Transformation” Journal of Physical Chemistry B 119, 12750 (2015).
Khoa Pham, Gangadhar Dhulipala, Walter G. Gonzalez, Bernard Gerstman, Chola Regmi, Prem P. Chapagain, and Jaroslava Miksovska “Ca2+ and Mg2+ modulate conformational dynamics and stability of Downstream Regulatory Element Antagonist Modulator” Protein Science, 24, 741 (2015).
Kevin M. Dean, Jennifer L. Lubbeck, Lloyd M. Davis,  Chola K. Regmi, Prem P. Chapagain,  Bernard S. Gerstman, Ralph Jimenez, and Amy E. Palmer “Microfluidics-based selection of red-fluorescent proteins with decreased rates of photobleaching” Integrative Biology, 7, 263 (2015).
Jeevan B. GC, Yuba R. Bhandari, Bernard S. Gerstman, and Prem P. Chapagain “Molecular Dynamics Investigations of the a-Helix to β-Barrel Conformational Transformation in the RfaH Transcription Factor” Journal of Physical Chemistry B 118, 5101–5108 (2014).
Patrick Konold, Chola K. Regmi, Prem P. Chapagain, Bernard S. Gerstman, and Ralph Jimenez “Hydrogen Bond Flexibility Correlates with Stokes Shift in mPlum Variants” Journal of Physical Chemistry B 118, 2940 (2014).

More Articles:



2012 - Prem Chapagain