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Every bacterial pathogen 88888 has at least one type IA topoisomerase, providing a target for discovery of new antibiotics to combat multi-drug resistant infections, including MDR- and XDR-TB. The study of the structure and mechanism of bacterial topoisomerase I provide the basic foundation for translational application of this enzyme as a novel antibacterial target. Drug discovery research extends to anticancer drugs targeting human DNA topoisomerases. The control of DNA structure by DNA topoisomerases can affect stress response and genomic stability, with implications for bacterial pathogenesis and cancer.