QBIC JC Schedule

QBIC Journal Club Schedule & Assigned Readings
Juniors - Fall 2018

revised 14 Aug, 2018.

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Date	Class Topic / Activity	Read for Today	Assignments Due Today
20-22 Aug	discussion & class planning	Syllabus	show up.
27-29 Aug	Membrane proteins: Aquaporin	CRITICAL SUMMARIES Model Critical Summary Agre P. The Aquaporin Water Channels Agre, P. and Kozono, D. (2003). Aquaporin water channels: molecular mechanisms for human diseases. FEBS Lett 555, 72-78. Preston GM, Carroll TP, Guggino WB, Agre P (1992). Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein. Science 256 (5055): 385–387.	The first two reviews are useful for background but do not critique them. Write a critical summary of Preston et al. (1992) and one other paper from the primary literature of your choosing.
3-5 Sep	NO CLASS - thank the workers of America.
10-12 Sep	Protein trafficking and endocytosis	Markham MR, McAnelly ML, Stoddard PK, Zakon HH (2009) Circadian and social cues regulate ion channel trafficking. PLoS Biology 7(9), e1000203.	Critical summary of Markham et al. (2009), AND explain its connection to the work of Randy W. Schekman, Thomas C. Südhof or James E. Rothman, 3 cell biologists who won the 2013 Nobel Prize for their studies of molecular trafficking
17-19 Sep	Protein folding and conformation - mechanism underlying infectious proteins.	Pan KM, Baldwin M, Nguyen J, Gasset M, Serban A, Groth D, Mehlhorn I, Huang Z, Fletterick RJ, Cohen FE, Mehlhorn I, Huang Z, Fletterick RJ, Cohenu FE, Prusiner SB. 1993. Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. Proc Natl Acad Sci U S A 90, 10962-10966.	Critical summary of Pan et al. (1993) and one other paper from the primary literature on same topic. (Pan et al. is a bit chewey but important – Stanley Prusiner's work was awarded the Nobel Prize)
24-26 Sep	Ubiquitin system & Autophagy	Kim PK, Hailey DW, Mullen RT, Lippincott-Schwartz J. (2008) Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes. Proc Natl Acad Sci USA 105:20567-74	Critical summary of Kim et al. (2008).
1-3 Oct	Nuclear pores	Patel SS, Belmont BJ, Sante JM, Rexach MF (2007) Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex. Cell 129:83-96	Critical summary of Patel et al. (2007).
8-10 Oct	Surprising roles of the humble nucleolus	Leslie M (2014) Central command. Science 345: 506-507. Rubbi CP1, Milner J (2003) Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses. EMBO J. 22:6068-77.	Leslie (2014) is background. Critique Rubbi & Milner (2003) and one other paper from the primary literature on the same subject.
15-17 Oct	Motor proteins - molecules that walk	Asbury, C.L., 2005. Kinesin: world's tiniest biped. Curr Opin Cell Biol 17, 89-97. Yildiz, A., Tomishige, M., Vale, R.D., Selvin, P.R., 2004. Kinesin walks hand-over-hand. Science 303, 676-678.	Critical summary of Yildiz et al. (2004). Make an effort to to understand each of the figures.
22-24 Oct	Mitochondrial reticulum	Glancy B, Hartnell LM, Malide D, Yu ZX, Combs CA, Connelly PS, Subramaniam S, Balaban RS (2015) Mitochondrial reticulum for cellular energy distribution in muscle. Nature, 523, 617-20. 10.1038/nature14614	Read cool but difficult paper. Read cursorally and create a glossary of terms and abbreviations. Read the paper again, slowly and carefully, as many times as you need to understand every figure. Write a critical summary (submit glossary and crit summary together to Turnitin).
29-31 Oct	Cytoskeleton: role in cell motility	Yang C, Hoelzle M, Disanza A, Scita G, Svitkina T (2009) Coordination of membrane and actin cytoskeleton dynamics during filopodia protrusion. PLoS ONE 4(5): e5678. doi:10.1371/journal.pone.0005678	Critical summary of Yang et al. (2009)
5-7 Nov	Insulin signaling: resveratrol and lifespan	Baur J and 26 other authors (2006). Resveratrol improves health and survival of mice on a high- calorie diet. Nature. 444:337-342.	Critical summary of Baur et al. (2006) a paper which illustrates the term "et al." Find a more recent paper from primary literature and address its findings as well.
12-14 Nov	NO CLASS - thank a veteran.
19-21 Nov	Cell cycle	Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM (2004) Accelerated telomere shortening in response to life stress. PNAS 101 (49) 17312-17315	Critical summary of Epel et al. (2004) and one more recent paper of your choosing from the primary literature on telomeres.
26-28 Nov	The cell cycle matters	Ma, H., Marti-Gutierrez, N., Park, S.-W., Wu, J., Lee, Y., Suzuki, K., Koski, A., Ji, D., Hayama, T., Ahmed, R., Darby, H., Van Dyken, C., Li, Y., Kang, E., Park, A. R., Kim, D., Kim, S.-T., Gong, J., Gu, Y., Xu, X., Battaglia, D., Krieg, S. A., Lee, D. M., Wu, D. H., Wolf, D. P., Heitner, S. B., Belmonte, J. C. I., Amato, P., Kim, J.-S., Kaul, S. & Mitalipov, S. 2017, Correction of a pathogenic gene mutation in human embryos. Nature, 548, 413-419.	Critical summary of Ma et al. (2017) alone, so make it good.
3-5 Dec	Cancer (No class today, just submit the notes).	Hanahan, D., Weinberg, R.A., 2011. Hallmarks of cancer: the next generation. Cell 144, 646-674.	Read this mongo review paper just through page 657, column 1. Take notes on what you learn and new terms. Submit to Turnitin. Your notes should come to at least 5 pages, single-spaced. Outline format is smart but not obligatory. You can read the rest of the paper if you like.