Histones

Eastern oyster epigenetics work accepted in Aquatic Toxicology!

Posted by | DNA, Epigenetics, FIU, Histones, Marine Biology, Oysters, Red Tides, Toxicology | No Comments

Our latest work “Effects of Florida Red Tides on histone variant expression and DNA methylation in the Eastern oyster Crassostrea virginica” has been accepted for publication in the journal Aquatic Toxicology (3.557 impact factor, ranked 3/104 in Marine & Freshwater Biology). The unformatted version of the paper is available at http://www.sciencedirect.com/science/article/pii/S0166445X17300760 and HERE. This work was developed by our lab at FIU (Environmental Epigenetics group, Dept. Biology, Institute of Water and Environment, CREST Center for Aquatic Chemistry and Environment) in collaboration with the Ecotoxicology Lab (SERC) and the University of Vigo, in Spain. We also collaborated with Rookery Bay National Estuarine Research Reserve during this research. Our results provide a basis to better understand how Florida Red Tides affect oysters and epigenetic mechanisms participating in their responses to environmental stress, opening new avenues to incorporate environmental epigenetics approaches into management and conservation programs. We are currently building on this work in collaboration with Mote Marine Lab as well as with aquaculture stakeholders in south and central Florida.

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Ciro Rivera-Casas awarded Ph.D. prize and postdoc fellowship

Posted by | Awards, Chromatin, Education, FIU, Histones | No Comments

Ciro Rivera-Casas (Chromevol’s former Ph.D. student at the University of A Coruna) has been awarded the University’s special prize for his Ph.D. dissertation focused on the characterization of chromatin and histone variants in marine invertebrates. But the celebration is double, as Ciro has been also awarded a 2 year postdoctoral fellowship funded by the Ramon Areces Foundation to join Chromevol at FIU. Congratulations sir!!Chromevol_Picture

Chromevol is back from ACCEC 2015, Asilomar chromatin is back!

Posted by | Cellular biology, Chromatin, Conference, Epigenetics, Histones, Research | No Comments

Last week we attended the 37th Asilomar Chromatin, Chromosomes and Epigenetics Conference (asilomarchromatin.com) in Pacific Grove, CA. It was a great opportunity to interact with old and new colleagues as well as to enjoy the beautiful setting of this conference in the Monterey peninsula. We had the chance of presenting our research in three talks, including our latest work about histone macroH2A in invertebrates (now under review), network analyses in environmental epigenetic responses and chromatin specialization in marine organisms. Overall it was a great experience (and we had the chance of experiencing the winter for a few days before returning to south Florida!). We’re looking forward for next year’s edition already!

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Graduate Students wanted!

Posted by | Education, Epigenetics, FIU, Histones, Marine Biology, Omics, Research | No Comments

Graduate Student (PhD) positions available in Dr. Eirin-Lopez’s Chromatin Structure & Evolution Lab (Department of Biological Sciences, Florida International University) starting in Fall 2016.

We are looking for enthusiastic, dynamic and independent students broadly interested in studying the interface between evolution, epigenetics and adaptation in marine organisms. Students would ideally have a B.S. degree in Biology or related discipline (academic training in biology, statistics, genetics and evolution) and must be proficient in English (both spoken and written). Candidates with additional knowledge on computer science and/or bioinformatics are encouraged to apply. Our research addresses the study of chromatin and epigenetics from different perspectives, most notably evolution, development and adaptation. To this end we use marine invertebrates as model systems in the lab, as well as a wide range of eukaryote groups in molecular evolutionary analyses. Our current projects combine elements from marine biology, toxicology, molecular biology, biochemistry, next generation sequencing, bioinformatics and molecular evolution to address environmental problems in the oceans. Our work requires good organizational and computational skills and the ability to work collaboratively as part of a team. Detailed information about our research is available at our website (chromevol.com). Follow us in Facebook (facebook.com/chromevol) and Twitter (@chromevol)

Potential research topics include (but are not limited to):

1) Characterization of epigenetic mechanisms underlying environmental responses and adaptation in marine invertebrates. This research addresses the roles of DNA methylation, histone variant modifications and other epigenetic mechanisms during responses to environmental stressors, notably by using bivalve molluscs and corals as model organisms.

2) Development of high-throughput “-omic” tools improving pollution biomonitoring in coastal areas. This topic focuses on the development of methods that can be routinely used to identify early exposure of marine organisms to genotoxic pollutants (e.g., microarrays, qPCR, proteomic analyses, etc.), specially in the case of commercially relevant shellfish, marine mammals and other megafauna.

3) Molecular evolutionary and phylogenetic analysis of chromosomal proteins in metazoans. This objective builds on the molecular evolutionary tradition of our group, studying the mechanisms governing the diversification/differentiation of gene and protein families across eukaryotes and their consequences for organismal evolution.

Related research topics are also welcome. Interested students will be required to apply to the Graduate Program in the Dept. of Biological Sciences at FIU (http://biology.fiu.edu/graduate/). Acceptance in the lab will be subject to successful application for Teaching Assistantship funds (TAs). Interested students are also strongly encouraged to apply for graduate research fellowships (e.g., National Science Foundation Graduate Research Fellowship). In order to be considered, qualified candidates must submit a statement of interest, curriculum vitae, unofficial transcripts (GPA scores), GRE scores, TOEFL scores (if applicable) and summary of research interests in a single PDF file to Dr. Eirin-Lopez (jeirinlo@fiu.edu). To receive full consideration, applications and required materials should be received as soon as possible, and never later than November 30th.

 

See ad with more details here.

Asilomar Chromatin, Chromosomes and Epigenetics Conference 2015

Posted by | Chromatin, Conference, Epigenetics, Histones, Research | No Comments

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The 37th edition of the Asilomar Chromatin, Chromosomes and Epigenetics Conference (ACCEC) is rolling and has renewed energies! Dr. Eirin-Lopez has joined the organizing committee of this meeting. Following a long scholar tradition, we’ll be gathering next December in Asilomar, Pacific Grove (CA) to discuss the latest advances in the field. Please check the revamped website for the meeting at:

website: asilomarchromatin.com

facebook: facebook.com/asilomarchromatin

twitter: twitter.com/asilomar_accec

ACCEC is an extraordinary opportunity for graduate students, postdocs and PIs to present their work (oral communications only!) in a relaxed environment in front of a diverse audience. The present edition has special focus on epigenetics and nutrition, among other topics.

Congratulations to Dr. Rivera-Casas!

Posted by | Awards, Chromatin, Evolution, Histones, Marine Biology, Research | No Comments

Yesterday Chromevol’s graduate student Ciro Rivera-Casas defended (with great success!) his Ph.D. dissertation entitled “Histone variants in marine invertebrates: chromatin analysis and characterization of macroH2A and H2A.Z.2 variants in bivalve molluscs”. Ciro joined Chromevol in 2010 and is the second Ph.D. student graduating under Dr. Eirin-Lopez’s supervision. We want to make you all participants of his achievement and we hope he can visit us soon in Miami to tell us more about his research!

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Environmental epigenetics meets marine invertebrates

Posted by | Chromatin, DNA, Epigenetics, Histones, Marine Biology, Omics, Toxicology | No Comments

Environmental epigenetics investigates the cause-effect relationships between specific environmental factors and the subsequent epigenetic modifications triggering adaptive responses in the cell. Given the dynamic and potentially reversible nature of the different types of epigenetic marks, environmental epigenetics constitutes a promising venue for developing fast and sensible biomonitoring programs. Indeed, several epigenetic biomarkers have been successfully developed and applied in traditional model organisms (e.g., human and mouse). Nevertheless, the lack of epigenetic knowledge in other ecologically and environmentally relevant organisms has hampered the application of these tools in a broader range of ecosystems, most notably in the marine environment.

Fortunately, that scenario is now changing thanks to the growing availability of complete reference genome sequences along with the development of high-throughput DNA sequencing and bioinformatic methods. Altogether, these resources make the epigenetic study of marine organisms (and more specifically marine invertebrates) a reality.

vicky_600x400rodri_600x400We have built on this knowledge to develop a review/perspectives paper on this topic, recently published in the journal Marine Pollution Bulletin. This work (conducted by Victoria Suarez-Ulloa and Rodrigo Gonzalez-Romero, grad student and postdoc at Chromevol, respectively) provides a timely perspective highlighting the extraordinary potential of environmental epigenetic analyses as a promising source of rapid and sensible tools for pollution biomonitoring, using marine invertebrates as sentinel organisms. This strategy represents an innovative, groundbreaking approach, improving the conservation and management of natural resources in the oceans.

 

Ciro Rivera-Casas’ PhD dissertation is finished!

Posted by | Chromatin, DNA, Education, Genetics, Histones, Molecular biology, Research | No Comments

Our own Ciro Rivera-Casas is about to defend his Ph.D. dissertation! we’re really excited after checking the final printed copy of his work! During the last 5 years, Ciro has been focused on the characterization of histone variants in marine invertebrates and the methodologies for the study of chromatin in these organisms. Along the way, he has discovered several interesting and unexpected features of these proteins that soon will be published as part of his Ph.D. work. Congratulations to Ciro and best of luck for the defense of his work this summer!

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2015 Glaser week finished

Posted by | Chromatin, Education, FIU, Histones | No Comments

This week we have been honored by the visit of Dr. Steven Henikoff (Fred Hutchinson Cancer Research Center, Howard Hughes Medical Institute, Seattle) within the framework of the 2015 Distinguished Glaser Seminar Series at FIU. During six days, Dr. Henikoff has provided faculty and students with a depth and breadth into chromatin and epigenetics research, making emphasis on the latest developments in this exciting discipline. From FIU we want to thank Dr. Henikoff for his collegiality, rapport and kindness during his visit.

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As part of the social events in the Glaser Seminar program we had the opportunity of visiting the Everglades National Park under the expert guidance of Dr. Jennifer Richards (r), with Steven Henikoff (c) and Chema Eirin-Lopez (l).