The Tse-Dinh Lab

INQUIRIES FOR RESEARCH AND COLLABORATIVE OPPORTUNITIES

 

Yuk-Ching Tse-Dinh, Ph.D.
Founding Director, Biomolecular Sciences Institute 
Distinguished University Professor, Department of Chemistry & Biochemistry
Florida International University
AHC4-210, 
11200 SW 8th Street 
Miami, FL 33199 
Tel: (305)348-4956
email: yukching.tsedinh@fiu.edu

1. Discovery of novel antibacterial lead compounds targeting bacterial topoisomerase I

Leads for novel antibiotics are urgently needed to combat bacterial pathogens resistant to current treatment. Enzyme based and cell based high throughput screening (HTS) assays are being developed and utilized to identify inhibitors that can act on bacterial topoisomerase I as mode of action. Hit compounds from HTS are being analyzed for SAR.