Epigenetics

Chromevol is back from ACCEC 2015, Asilomar chromatin is back!

Posted by | Cellular biology, Chromatin, Conference, Epigenetics, Histones, Research | No Comments

Last week we attended the 37th Asilomar Chromatin, Chromosomes and Epigenetics Conference (asilomarchromatin.com) in Pacific Grove, CA. It was a great opportunity to interact with old and new colleagues as well as to enjoy the beautiful setting of this conference in the Monterey peninsula. We had the chance of presenting our research in three talks, including our latest work about histone macroH2A in invertebrates (now under review), network analyses in environmental epigenetic responses and chromatin specialization in marine organisms. Overall it was a great experience (and we had the chance of experiencing the winter for a few days before returning to south Florida!). We’re looking forward for next year’s edition already!

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Chromevol’s research featured at AMLC’s bulletin!

Posted by | Conference, corals, Epigenetics, Evolution, Marine Biology, Research | No Comments

This month’s edition of the Notes of the Association of Marine Laboratories of the Caribbean (AMLC) features our research group!

AMLC is a confederation of 27 marine research, education, and resource management institutions endeavoring to encourage the production and exchange of research and resource management information, advance the cause of marine and environmental education in the region, and facilitate cooperation and mutual assistance among its membership. AMLC also has more than 500 Individual Members with professional research and management interests in the Region. We presented our work at the AMLC meeting in Curaçao last May and we’ll repeat for sure in the next edition (Cancun 2017).

Chromevol’s Sean Campbell at the McNair Conference

Posted by | Conference, corals, Education, Epigenetics, Research | No Comments

Last Friday, Sean Campbell (undergraduate student volunteer at Chromevol) got his first shot at presenting in a scientific meeting! Sean presented preliminary results from the project “Epigenetic responses to nutrient loading the staghorn coral Acropora cervicornis“, on which he collaborates, at the FIU McNair Scholars Research Conference. This study is the result from fieldwork done during last summer in collaboration with Deron Burkepile’s lab at UC Santa Barbara. Our experiments with corals are consistently moving forward showing very interesting results, more info soon! Congrats Sean!!

Graduate Students wanted!

Posted by | Education, Epigenetics, FIU, Histones, Marine Biology, Omics, Research | No Comments

Graduate Student (PhD) positions available in Dr. Eirin-Lopez’s Chromatin Structure & Evolution Lab (Department of Biological Sciences, Florida International University) starting in Fall 2016.

We are looking for enthusiastic, dynamic and independent students broadly interested in studying the interface between evolution, epigenetics and adaptation in marine organisms. Students would ideally have a B.S. degree in Biology or related discipline (academic training in biology, statistics, genetics and evolution) and must be proficient in English (both spoken and written). Candidates with additional knowledge on computer science and/or bioinformatics are encouraged to apply. Our research addresses the study of chromatin and epigenetics from different perspectives, most notably evolution, development and adaptation. To this end we use marine invertebrates as model systems in the lab, as well as a wide range of eukaryote groups in molecular evolutionary analyses. Our current projects combine elements from marine biology, toxicology, molecular biology, biochemistry, next generation sequencing, bioinformatics and molecular evolution to address environmental problems in the oceans. Our work requires good organizational and computational skills and the ability to work collaboratively as part of a team. Detailed information about our research is available at our website (chromevol.com). Follow us in Facebook (facebook.com/chromevol) and Twitter (@chromevol)

Potential research topics include (but are not limited to):

1) Characterization of epigenetic mechanisms underlying environmental responses and adaptation in marine invertebrates. This research addresses the roles of DNA methylation, histone variant modifications and other epigenetic mechanisms during responses to environmental stressors, notably by using bivalve molluscs and corals as model organisms.

2) Development of high-throughput “-omic” tools improving pollution biomonitoring in coastal areas. This topic focuses on the development of methods that can be routinely used to identify early exposure of marine organisms to genotoxic pollutants (e.g., microarrays, qPCR, proteomic analyses, etc.), specially in the case of commercially relevant shellfish, marine mammals and other megafauna.

3) Molecular evolutionary and phylogenetic analysis of chromosomal proteins in metazoans. This objective builds on the molecular evolutionary tradition of our group, studying the mechanisms governing the diversification/differentiation of gene and protein families across eukaryotes and their consequences for organismal evolution.

Related research topics are also welcome. Interested students will be required to apply to the Graduate Program in the Dept. of Biological Sciences at FIU (http://biology.fiu.edu/graduate/). Acceptance in the lab will be subject to successful application for Teaching Assistantship funds (TAs). Interested students are also strongly encouraged to apply for graduate research fellowships (e.g., National Science Foundation Graduate Research Fellowship). In order to be considered, qualified candidates must submit a statement of interest, curriculum vitae, unofficial transcripts (GPA scores), GRE scores, TOEFL scores (if applicable) and summary of research interests in a single PDF file to Dr. Eirin-Lopez (jeirinlo@fiu.edu). To receive full consideration, applications and required materials should be received as soon as possible, and never later than November 30th.

 

See ad with more details here.

Personalized epigenetics and the future of health sciences

Posted by | Bioinformatics, Epigenetics, FIU, Omics, Research | No Comments

The latest publication resulting from our ongoing collaboration with the Bioinformatics Research Group (BioRG) at FIU’s School of Computing & Information Sciences is now available!. In this work (Computational methods in epigenetics), BioRG’s postdoc Dr. Vanessa Aguiar-Pulido (L) and Chromevol’s graduate student Victoria Suarez-Ulloa (R) lead a revision describing the main characterisitics of the various types of data generated during epigenetic studies, providing a description of the most common computational approaches used for their integrative analysis. Congratulations for such a wonderful job!

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Asilomar Chromatin, Chromosomes and Epigenetics Conference 2015

Posted by | Chromatin, Conference, Epigenetics, Histones, Research | No Comments

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The 37th edition of the Asilomar Chromatin, Chromosomes and Epigenetics Conference (ACCEC) is rolling and has renewed energies! Dr. Eirin-Lopez has joined the organizing committee of this meeting. Following a long scholar tradition, we’ll be gathering next December in Asilomar, Pacific Grove (CA) to discuss the latest advances in the field. Please check the revamped website for the meeting at:

website: asilomarchromatin.com

facebook: facebook.com/asilomarchromatin

twitter: twitter.com/asilomar_accec

ACCEC is an extraordinary opportunity for graduate students, postdocs and PIs to present their work (oral communications only!) in a relaxed environment in front of a diverse audience. The present edition has special focus on epigenetics and nutrition, among other topics.

Environmental epigenetics meets marine invertebrates

Posted by | Chromatin, DNA, Epigenetics, Histones, Marine Biology, Omics, Toxicology | No Comments

Environmental epigenetics investigates the cause-effect relationships between specific environmental factors and the subsequent epigenetic modifications triggering adaptive responses in the cell. Given the dynamic and potentially reversible nature of the different types of epigenetic marks, environmental epigenetics constitutes a promising venue for developing fast and sensible biomonitoring programs. Indeed, several epigenetic biomarkers have been successfully developed and applied in traditional model organisms (e.g., human and mouse). Nevertheless, the lack of epigenetic knowledge in other ecologically and environmentally relevant organisms has hampered the application of these tools in a broader range of ecosystems, most notably in the marine environment.

Fortunately, that scenario is now changing thanks to the growing availability of complete reference genome sequences along with the development of high-throughput DNA sequencing and bioinformatic methods. Altogether, these resources make the epigenetic study of marine organisms (and more specifically marine invertebrates) a reality.

vicky_600x400rodri_600x400We have built on this knowledge to develop a review/perspectives paper on this topic, recently published in the journal Marine Pollution Bulletin. This work (conducted by Victoria Suarez-Ulloa and Rodrigo Gonzalez-Romero, grad student and postdoc at Chromevol, respectively) provides a timely perspective highlighting the extraordinary potential of environmental epigenetic analyses as a promising source of rapid and sensible tools for pollution biomonitoring, using marine invertebrates as sentinel organisms. This strategy represents an innovative, groundbreaking approach, improving the conservation and management of natural resources in the oceans.